Postpartum endometritis is commonly treated with which antibiotic combination?

• A. Clindamycin and Gentamicin
• B. Penicillin and Streptomycin
• C. Doxycycline alone
• D. Erythromycin and Cephalexin

Answer: (A)

Postpartum endometritis is usually a polymicrobial infection from vaginal flora, involving anaerobes and gram-negative bacteria. Treatment needs broad coverage of both groups to effectively control the infection. Clindamycin provides strong anaerobic coverage and covers many Gram-positive cocci, while gentamicin covers gram-negative aerobic bacteria. Together, they address the organisms most commonly implicated in postpartum endometritis and are a standard empiric choice for hospitalized patients after delivery. Other regimens may lack adequate anaerobic coverage or narrower spectra, making them less appropriate as initial therapy.